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Azizeh-Mitra (Amy) Yousefi

Associate Professor and Schallek Endowed Chair
Paper & Chemical Engineering

Office Address: 64 M Engineering Building, Miami University, Oxford, Ohio 45056

OFFICE PHONE: (513) 529-0766
E-MAIL ADDRESS: moshiray(at)muohio.edu

EDUCATION:

    Ph.D. - École Polytechnique, University of Montreal, Montreal Canada-1996, Chemical-Mechanical Engineering

    M.S. - Amir-Kabir University (Polytechnic), Tehran Iran-1990, Chemical Engineering

    B.S. - Amir-Kabir University (Polytechnic), Tehran Iran -1988, Chemical Engineering

OTHER RELATED EXPERIENCES:

    Industrial:

      Industrial Materials Institute, National Research Council Canada, 1999-2009

    Research Interests:

    • Numerical modeling for biomedical device design and Industrial resin/part design applications
    • Biomechanics of biological tissues (hyperelastic, visoelastic, biphasic ...)
    • Scaffolds and nano-composites for tissue engineering, gene therapy and drug delivery
    • Biomaterials: design, solid freeform fabrication, surface treatment (nano patterning)
    • Biomimetic hydrogels/phantoms for haptic tuning, MRE, MRI and drug delivery applications
    • Multiscale modeling (tissue level, cellular level, and nano scale)
    • Multiscale modeling for microstructure - performance prediction
    • Computational fluid dynamics (CFD), transport phenomena (heat and mass transfer)
    • Solid mechanics: constitutive models (hyperelastic, viscoelastic...)
    • Polymer forming operations, polymer processing for automotive industry (SBM/EBM)
    • Polymer rheology, material charaterization, kinetics of polymer degradation and tissue growth
    • Polymer composites, thermosetting reactions, reactive processing (RTM, RIM)

PUBLICATIONS AND PAPERS:

     Papers in Refereed Journals

  • Daniel L. Coutu, Jessica Cuerquis, Rouwayda El Ayoubi, Kathy-Ann Forner, Ranjan Roy, Moira Francois, Alex Hyatt, may Griffith, Azizeh-Mitra Yousefi, Mark D. Blostein & Jacques Galipeau, "Engineering Optimized 3D Biocompatible Porous Scaffolds for Mesenchymal Stromal Cell-Based Gene Therapy of Hemophilia B" submitted to Nature Biotechnology, 2009.

  • Daniel L. Coutu, Azizeh-Mitra Yousefi, Jacques Galipeau, "Three Dimensional Porous Scaffolds at the Crossroads of Tissue Engineering and Cell-Based Gene Theraphy", accepted review paper, Journal of Celluar Biochemistry, 2009.

  • Azizeh-Mitra Yousefi, Japp den Doelder, Marc-André Rainville, and Kurt A. Koppi, "A Modeling Approach to the Effect of Resin Charateristics on Parison Formation in Extrusion Blow Molding", Polym. Eng. Sci., 49, 251-263, 2009.

  • A.M. Yousefi and H. Atsbha, "Modeling of Complex Parison Formation in Extrusion Blowing: Medium to Large Die-Head Size and Fuel Tank Geometry", Polym. Eng. Sci., 49, 229-239, 2009.

  • R. El-Ayoubi, N. Eliopoulos, R. DiRaddo, J. Galipeau, and A. M. Yousefi, "Design and Fabrication of 3D Porous Scaffolds to Promote Cell-Based Gene Therapy”, Tissue Engineering, 14, 1037-1048, 2008.

  • Azizeh-Mitra Yousefi, “3D Scaffolds Deliver Tissue Growth”, NRC Newslink, summer issue, 2008. 

  • Rouwayda El-Ayoubi, Christian De Grandpré, Robert DiRaddo, Patrick Lavigne, Azizeh-Mitra Yousefi, “Design and Dynamic Culture of 3D Scaffolds for Cartilage Tissue Engineering”, submitted to Annals of Biomedical Engineering, 2008.

  •  A.M. Yousefi , C. Gauvin, L. Sun, R.W. DiRaddo, and J. Fernandes, “Design and Fabrication of 3D-Plotted Polymeric Scaffolds in Functional Tissue Engineering”, Polym Eng Sci., 47, 5, 608-618, 2007.

  • A.M. Yousefi, P. Collins, S. Chang, and R.W. DiRaddo, “A Comprehensive Experimental Study and Numerical Modeling of Parison Formation in Extrusion Blow Molding”, Polym. Eng. Sci., 47, 1, 1-13, 2007.

  • A.M. Yousefi, D. Laroche, P. Collins, and R. DiRaddo, “A New Hybrid Approach for the Prediction of Parison Swell in Extrusion Blow molding”, SPE Blow molding newsletter, Spring Edition, 2003.

  • A. Yousefi, A. Bendada, and R. Diraddo, “Improved Modeling for the Reheat Phase in Thermoforming through an Uncertainty Treatment of the Key Parameters”, Polym. Eng. Sci., 42 (5), 1115-1129, 2002.

  • A. Yousefi, P.G. Lafleur, and R. Gauvin, “Numerical Analysis of Promoted Polyester and Vinylester Reinforced Composites in RTM Molds”, Polym. Eng. Sci., 37(5), 757-771, 1997.

  • A. Yousefi, P.G. Lafleur, and R. Gauvin, “The Effects of Cobalt Promoter and Glass Fibers on the Curing Behavior of Un-saturated Polyester Resin”, J. Vinyl Additives. Tech., 3(2), 157-169, 1997.

  • A. Yousefi, P.G. Lafleur, and R. Gauvin, ”Kinetic Studies of Thermoset Cure Reactions - A Review”, Polym. Comp., 18(2), 157-168, 1997.

  • A. Yousefi and A.A. Katbab, “Post Irradiation Degradation of Polypropylene, Radiation Durability of Polypropylene Stabilized with Phenolic Stabilizer(II)”, Radiat. Phys. Chem., 44(6), 645-651, 1994.

  • S. Hassanpour and A. Yousefi, “Radiation Stabilization of Polypropylene by Phenolic Stabilizers”, Radiat. Phys. Chem., 42(1-3), 223-227, 1993.

  • A.A. Katbab and A. Y. Moushirabadi, "Post-Irradiation Degradation of Polypropylene: Comparison of Hindered Aromatic Phenol and Amine as Gamma Stabilizer-I", Radiat. Phys. Chem., 38(3), 295-301, 1991.

     Invited-Keynote Talks:

  • F. Thibault, A.M. Yousefi, H. Atsbha, R. DiRaddo, “Modeling of Parison Formation and Process Optimization for Blow Molded Parts”, PPS-22 (Keynote Speaker), Yamagata, July 2-6, 2006.

  • A.M. Yousefi, “Deformable Biostructures”, Seminar at Johnson & Johnson Center for Biomaterials & Advanced Technologies (Invited Speaker), Newark, Jan. 17, 2006.

  • A.M. Yousefi, “Overview of Research Activities at IMI-NRC”, Seminar at the University of Michigan (Invited Speaker), Ann Arbor, April 2004.

  • A. Yousefi, “New Approaches to the prediction of the Injection Stretch Blow Moulding of PET: Reheat to Stretch/Inflation to Part Solidification”, NOVA-PACK AMERICAS 2003 (Invited Speaker), Feb. 3-4, Orlando, 2003.

  • A. Yousefi, “Computer Simulation of Blow Molding”, High Production Blow Molding Workshop (Invited Speaker), Aug. 27-29, Michigan, 2001.

     Refereed Conference Proceedings

  • A.M. Yousefi, P. Latta, P. Debergue, C. Bowman, C. Kazina, M.A. Rainville, C. DeGrandpré, and R. DiRaddo, “Design and Characterization of Tissue-Mimicking Gel Phantoms for Neurosurgical Simulation”, Society for Simulation in Healthcare Annual Meeting, Jan. 10-14 (2009)

  • A.M. Yousefi and H. Atsbha, “Modeling of complex parison formation in extrusion blow molding”, SPE Annual Blow Molding Conference, Oklahoma, Oct. 8-9 (2008)

  • A.M. Yousefi, Jaap den Doelder, Marc-André Rainville, and Kurt A. Koppi, “A modeling approach to the effect of resin characteristics on parison formation in extrusion blow molding”, SPE Annual Blow Molding Conference, Oklahoma, Oct. 8-9 (2008).

  • A.M. Yousefi, P. Debergue, P. Latta, G. Campbell, R. DiRaddo, “Towards Tissue-Mimicking Gel Phantoms for Neurosurgical Simulation”, NRC Genomics and Health Initiative, 8th Annual General Meeting, Saskatoon, Sept. 21-24, 2008.

  • P. Debergue, D. Laroche, A.M. Yousefi, R. DiRaddo, and H. Atsbha, “3D Finite Elements for the Prediction of Complex Distortions in the Extrusion Blow Moulding Process", 24th Annual Meeting of the Polymer Processing Society (PPS-24), Salerno, Italy, June 15-19 (2008).

  • D.L. Coutu, J. Cuerquis, R. El Ayoubi, A.M. Yousefi, M. Griffith, M. Blostein, J. Galipeau, “Tissue engineered organoids from MSC-derived chondrocytes and their use in the treatment of hemophilia B”, Miami, International Society for Cellular Therapy (ISCT) Annual Meeting, May 17-20 (2008).

  • G. Lamouche, C-E Bisaillon, M. Dufour, A.M. Yousefi, C. de Grandpré, and J.P. Monchalin, “Monitoring the dynamics of scaffold fabrication using optical coherence tomography”, BIOS-SPIE Photonics West 2008, San Jose, USA, January 19-24, 2008.

  • R. El-Ayoubi, N. Eliopoulos, D. Coutu, R. DiRaddo, J. Galipeau, and A.M. Yousefi, “Towards computational design of 3D macro/microporous scaffolds for cell-based gene therapy”, Biovigilance workshop, Dec. 13, Montreal (2007).

  • P. Lavigne, R. El-Ayoubi, R. DiRaddo, and A.M. Yousefi, “Design and dynamic culture of macro/microporous scaffolds for cartilage tissue engineering”, International cartilage Repair Society, Warsaw, Poland, September 29-October 2, 2007.

  • R. El-Ayoubi, N. Eliopoulos, D. Coutu, R. DiRaddo, J. Galipeau, and A.M. Yousefi,“Towards computational design of 3D macro/microporous scaffolds for cell-based gene therapy”, North-American Regenerate Conference TERMIS-NA, Toronto, June 13-16, 2007.

  • G. Lamouche, M. Hewko, M.L. Dufour, D. Popescu, C.E. Bisaillon, A. Yousefi;R. El_Ayoubi, J.P. Monchalin, M. Sowa, ”Optical coherence tomography at NRC,” NRC Genomics and Health Initiative, 7th Annual General Meeting, Halifax, May 22-25, 2007.

  • P. Lavigne, R. El-Ayoubi, R. DiRaddo, and A.M. Yousefi, “Design and dynamic culture of macro/microporous scaffolds for cartilage tissue engineering”, 13th Canadian Connective Tissue Conference, Toronto, May 24-26, 2007.

  • P. Lavigne, R. El-Ayoubi, R. DiRaddo, and A.M. Yousefi, “Design and dynamic culture of macro/microporous scaffolds for cartilage tissue engineering”, SSHC CompMed Conference, Montreal, May 16-18, 2007.

  • J. Galipeau, R. El-Ayoubi, N. Eliopoulos, D. Coutu, R. DiRaddo, and A.M. Yousefi, “Towards computational design of 3D scaffolds for cell-based gene therapy”, SSHC CompMed Conference, Montreal, May 16-18, 2007.

  • A.M. Yousefi, D. Laroche, and R. DiRaddo, “3D computational modelling of drug elution from angioplasty stents”, SSHC CompMed Conference, Montreal, May 16-18, 2007.

  • G. Lamouche, M. Hewko, M.L. Dufour, C.E. Bisaillon, A. Yousefi; B. Gauthier , C. Padioleau , C. DeGrandpré, V. Bartulovic, M. Hewko, J.P. Monchalin, ”Bio-Material Characterization Using Optical Coherence Tomography (OCT),” SSHC CompMed Conference, Montreal, May 16-18, 2007.

  • R. El-Ayoubi, P. Lavigne, R. DiRaddo, and A.M. Yousefi, “Design and Dynamic Culture of Macro/Microporous Scaffolds for Cartilage Tissue Engineering”, 7e Journée de la Recherche du POES et de la Division d'orthopédie du département de chirurgie de l'Université de Montréal, Montreal’s Notre-Dame Hospital, Montreal, April 20, 2007.

  • R. DiRaddo, E. El-Ayoubi, and A.M. Yousefi, “Physical and Numerical Simulation of 3D Polymeric Scaffolds for Load-bearing Tissue Engineering and Cell-based Gene Therapy”, International Symposium on Polymeric Materials for Regenerative Medicine (PMRM), Montreal, April 2-4, 2007.

  • P. Lavigne, R. El-Ayoubi, A.M. Yousefi, “Propriétés histologiques et biomécaniques des réparations cartilagineuses”, la journée de génie tissulaire de l'association d'orthopédie du Québec, Sherbrooke, Nov. 18, 2006.

  • J. Fernandes, A.M. Yousefi, and R. DiRaddo, “Optimization and performance modeling of osteochondral scaffolds for tissue engineering”, World Congress on Tissue Engineering and Regenerative Medicine, Pittsburg, April 25-27, 2006.

  • C. Auclair-Daigle, A.M. Yousefi, C. Gauvin, R. DiRaddo, and J. Fernandes, “Optimisation de la performance des scaffolds ostéochondraux pour le génie tissulaire”, 25e journée de la recherche du PEOS, Montreal, May 6, 2005.

  • C. Gauvin, A.M. Yousefi, R.W. DiRaddo, and J. Fernandes, “Fabrication and performance modelling of 3d plotted osteochondral scaffolds for tissue engineering”, ISAB 2005, Montreal, April 3-6, 2005.

  • C. Auclair-Daigle, J. Fernandes, R.W. DiRaddo, A.M. Yousefi, C. Gauvin, and J. Zhu, “Osteochondral scaffolds for the replacement of articular cartilage by tissue engineering”, ISAB 2005, Montreal, April 3-6, 2005.

  • C. Gauvin, J. Reignier, A.M. Yousefi, M. Huneault, R.W. DiRaddo, “Fabrication of Novel Polymeric Scaffolds and Prediction of Performance in Functional Tissue Engineering”, Biomaterials in Regenerative Medicine: The Advent of Combination Products, Philadelphia, Pennsylvania, October 16-18, 2004.

  • C. Gauvin, A.M. Yousefi, R.W. DiRaddo, J. Fernandes, “Performance of Polymer-Tissue Constructs in Functional Tissue Engineering”, 13th biannual conference for the Canadian Society of Biomechanics, Halifax, Novo Scotia, August 4-7, 2004.

  • C. Gauvin, A.M. Yousefi, R.W. DiRaddo, “New Approaches to the Osteochondral Scaffold Design for Functional Tissue Engineering”, Gordon Research Conference on Musculoskeletal Biology and Bioengineering, Andover, New Hampshire, July 25-20, 2004.

  • C. Gauvin, A.M. Yousefi, R. DiRaddo, J. Fernandes, “Biphasic Modelling of Functional Tissue Engineering Scaffolds Surrounded By Native Tissues”, Symposium on Mechanics of Biological Tissue, Graz, Austria, June 27-July 2, 2004.

  • A.M. Yousefi, C. Gauvin, P. Debergue, D. Laroche, R. DiRaddo, and J. Fernandes, “Performance of Polymeric Scaffolds in Tissue Engineering”, ANTEC-2004, May 17-19, Chicago, 2003.

  • C.Gauvin, A.M. Yousefi, R.W. DiRaddo, and J. Fernandes, “Performance de la Structure Scaffold-Cartilage pour le Génie Tissulaire”, Journée de la recherche de l’HSCM, Hôpital du Sacré-Coeur de Montréal, May 21, 2004.

  • C. Gauvin, A.M. Yousefi, R.W. DiRaddo, and J. Fernandes, “Performance de la Structure Treillis-Cartilage Pour Le Génie Tissulaire”, Journée de la recherche du P.O.E.S. (Programme d’Orthopédie Edouard-Samson), Hôpital Ste-Justine, Montréal, May 14, 2004.

  • A.M. Yousefi, P. Collins, R. DiRaddo, “A Comprehensive Study of Die Geometry and Operating Condition Effects on Parison Dimensions”, ANTEC-2003, May 5-8, Nashville, 2003.

  • A.M. Yousefi, D. Laroche, P. Collins, R. DiRaddo, “A Hybrid Fluid Mechanics – Solid Mechanics approach for the prediction of parison Swell in Extrusion Blow molding”, 6th EsaForm Conference, Aug. 28-30, Salerno, Italy, 2003.

  • P. Girard, V. Thomson, B. Hou, A. Yousefi, R. DiRaddo, “Hybrid Model-based Soft Sensors for the On-Line Estimation of Sheet Temperature Distribution in Thermoforming”, ANTEC, May 5-8, Nashville, 2003.

  • P.Girard, B. Hou, V. Thomson, A. Yousefi, R.DiRaddo, “Simulation and Experimental Hybrid Model-based Soft Sensors for Intelligent Control of Forming Operations”,IPMM Annual Conference, Japan (2003).

  • A. Yousefi, A. Bendada, R. Diraddo, “Robust Simulation for the Heating Stage in Thermoforming”, ANTEC2001, Dallas, Texas, 2001.

  • A. Yousefi, R. Diraddo, A. Bendada, “Simulation of the Mobile Preform Reheat in Injection Stretch Blow Molding Process”, PPS-17, Montréal, 2001.

  • A. Yousefi, A. Bendada, R. Diraddo, 50th conference of CSChE, Montréal, 2000.

  • A. Yousefi, P.G. Lafleur, and R. Gauvin, ANTEC, Boston, USA.

  • S. Hassanpour and A. Yousefi, 8th International Symposium on Radiation, Beijing, China, 1992.

  • A. Yousefi and A.A. Katbab, 2nd Pacific Polymer Conference (PPC), Otsu, Japan, 1991.

  • A. Yousefi and A.A. Katbab, Polymer-91 Symposium, Melbourne, Australia, 1991.

  • A. Yousefi and A.A. Katbab, National Symposium of Chemistry and Chemical Engineering Society, Beheshti University, Tehran, 1991.

PATENTS:

  • A.M. Yousefi, C. DeGrandpré, R. El-Ayoubi, “Tissue Scaffold and Method of Fabrication Thereof”, U.S. Provisional Patent, 60/817,427 (2006).

  • G. Maurais, N. Huynh, R. DiRaddo, J. Fernandes, S. Delorme, and , A. Yousefi,“Methods for Regenerating Fractured and/or Diseased Vertebra”, Provisional Patent, IPS 11667 (April 29, 2005).

  • A.M. Yousefi, C. de Grandpré, G. Campbell, “Method of Producing Homogeneous Porous and Non-porous Tissue-mimicking Gel Phantoms”, Provisional Patent Application is submitted (2009).

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