School of Engineering & Applied Science

Justin Saul

Associate Professor Chemical and Paper Engineering

Office Address: 64 L Engineering Building, 650 East High Street, Miami University, Oxford, Ohio 45056

OFFICE PHONE: (513) 529-0769

E-MAIL ADDRESS: sauljm(at)muohio.edu

 

EDUCATION: 

POSTDOCTORAL TRAINING: University of Washington, Department of Bioengineering. September, 2005 – August, 2007. 

Ph.D., Biomedical Engineering, Case Western Reserve University. January, 2006. 

Bachelor of Science, Chemical Engineering, Purdue University. May, 1999.  

ACADEMIC APPOINTMENTS: 

Associate Professor of Chemical and Paper Engineering, Miami University, 2011 - present

Assistant Professor of Biomedical Engineering. Wake Forest University School of Health Sciences and Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, Winston-Salem, NC. November, 2007 – 2011. 

Assistant Professor, Wake Forest Institute for Regenerative Medicine. November, 2007 – 2011. 

EMPLOYMENT: 

Wake Forest University Health Sciences, Department of Biomedical Engineering; Institute for Regenerative Medicine. November, 2007 - 2011

Senior Fellow. University of Washington, Department of Bioengineering. September, 2005 – August, 2007.  

Graduate Research Assistant in PhD Program. Case Western Reserve University, Department of Biomedical Engineering. September, 1999 – September, 2005. 

Co-op Engineer – Polymer Process Development. SC Johnson Polymer, Racine, Wisconsin. January – August, 1998.  

Co-op Engineer - Manufacturing. SC Johnson Polymer, Racine, Wisconsin. August – December, 1996; May – August, 1997. Rodger Kruse, group leader. 

PROFESSIONAL APPOINTMENTS AND ACTIVITIES: 

Adjunct appointments 

  • Wake Forest University Comprehensive Cancer Center
  • Minority Access to Research Careers (MARC) Program – Winston-Salem State University 

PROFESSIONAL MEMBERSHIPS AND SERVICE: 

Society Memberships: 

  • Society for Biomaterials, 2002 – Present 
  • Controlled Release Society, 2002 
  • American Society for Gene Therapy, 2007-2008 
  • Tissue Engineering and Regenerative Medicine International Society, 2008 - Present 
  • Wake Forest Comprehensive Cancer Center, 2007- Present 
  • Biomedical Engineering Society, 2009-Present 

Reviewer: 

  • Acta Biomaterialia 2009 - Present 
  • Biomacromolecules 2009 – Present 
  • Molecular Pharmaceutics 2009 – Present 
  • Journal of Applied Polymer Science 2009 – Present 
  • Journal of Biomedical Nanotechnology 2008 - Present 
  • Methods 2008 – Present 
  • Nanomedicine 2010 - Present 
  • Journal of the American Chemical Society 2010 - Present 

Abstract reviewer: 

  • Society for Biomaterials 2008 – Present 
  • Biomedical Engineering Society 2010 

PROFESSIONAL INTERESTS: 

  • Controlled release and delivery of therapeutic agents including chemotherapy drugs, small molecule/peptide therapeutics, antibiotics, and nucleotides.
  •  The role of physical guidance cues in tissue engineering and regenerative medicine.
  •  Application of drug delivery systems to tissue engineering and regenerative medicine. 

BIBLIOGRAPHY: 

  • Peer-Reviewed Journal Articles: Kader, KN; Moore, LR; Saul, JM; Zborowski, M; Ziats, NP; Bellamkonda, RV. Isolation and purification of canine adipose microvascular endothelial cells. Microvascular Research, 61(2), 220-226, 2001. 

  • Saul, JM; Annapragada, A; Natarajan, JV; Bellamkonda, RV. Controlled targeting of liposomal doxorubicin via the folate receptor in vitro. Journal of Controlled Release, 92(1-2), 49-67, 2003. 

  • Ghaghada, KB; Saul, J; Natarajan, JV; Bellamkonda, RV; Annapragada, AV. Folate targeting of drug carriers: A mathematical model. Journal of Controlled Release, 104(1):113-128, 2005. 

  • Saul, JM; Annapragada, AV; Bellamkonda, RV. A dual ligand approach for enhancing selectivity of tumor-targeted drug delivery vehicles. Journal of Controlled Release, 114(3), 277-287, 2006. 

  • Saul, JM; Linnes, MP; Ratner, BD; Giachelli, CM; Pun, SH. Two-stage delivery of non-viral gene carriers from sphere-templated fibrin scaffolds for sustained transgene expression. Biomaterials, 28(31), 4705-4716, 2007. 

  • Saul, JM; Wang, CK; Ng, CP; Pun, SH. Multilayer nanocomplexes of polymer and DNA exhibit enhanced gene delivery. Advanced Materials, 20(1), 19-25, 2008. 

  • Scott, JB; Afshari, M; Kotek, R; Saul, JM. Polymer templated fibrin scaffolds promote axon extension in vitro. Submitted to Biomaterials. 

  •  Saul, JM; Ellenburg, MD; de Guzman, R.; Van Dyke, ME. Sustained release of bioactive ciprofloxacin from keratin hydrogels. Submitted to Journal of Biomedical Materials Research Part A. 

  • Kowalczewski, CJ; Saul, JM. Surface-mediated delivery of siRNA polyplexes effectively knocks down molecules inhibitory to peripheral nerve regeneration. In preparation. 

Book Chapters: 

  • Saul, JM and Williams, DF. Chapter 35: Hydrogels. In “Principles of Regenerative Medicine” (Editors: Atala, Lanza, Thomson, and Nerem), pages 637 – 662. Academic Press, Elsevier, NY, 2011. 

  • Saul, JM and Harrison, BS. Micro- and nano-scale delivery of therapeutic agents for Regenerative Therapy. In “Regenerative Pharmacology (Editors: Christ and Andersson). Cambridge Press, NY. Submitted. 

Abstracts/Presentations at National Meetings: 

  • Saul, JM; Annapragada, A; Bellamkonda, RV. Folate receptor-mediated delivery of doxorubicin to glioma. Society for Biomaterials Annual Conference Abstract and Podium Presentation, April, 2002, Tampa, FL. 

  • Saul, JM; Annapragada, A; Bellamkonda, RV. Tunable dosage of liposomal doxorubicin to tumor cell lines by folate targeting. Engineering Tissues Conference Abstract and Poster, February, 2003, Hilton Head, SC. 

  • Saul, JM; Annapragada, A; Bellamkonda, RV. Differential delivery of liposomal doxorubicin to cells via the folate receptor in vitro. 7th World Biomaterials Conference Abstract and Podium Presentation, May, 2004, Sydney, NSW, Australia. 

  • Saul, JM; Annapragada, AV; Bellamkonda, RV. Modulation of Tumor Cytotoxicity and Targeting Selectivity of Nanocarriers via a Dual Ligand Targeting Approach. Society for Biomaterials Annual Conference Abstract and Podium Presentation, April, 2006, Pittsburgh, PA. 

  • Saul, JM; Linnes, MP; Ratner, BD; Giachelli, CM; Pun, SH. Integration of DNA carriers and templated fibrin scaffolds for tissue engineering applications. Biomedical Engineering Society Abstract and Poster, October, 2006, Chicago, IL. 

  • Saul, JM; Linnes, MP; Ratner, BD; Giachelli, CM; Pun SH. Non-viral gene delivery from templated fibrin tissue engineering scaffolds for sustained transgene expression. American Society for Gene Therapy Abstract and Poster Presentation, May-June, 2007, Seattle, WA. 

  • Wang, CK; Saul, JM; Ng, CP; Pun, SH. Novel layer-by-layer polyplexes using poly(ethylenimine) and poly(acrylic acid) for gene delivery. American Society for Gene Therapy Abstract and Podium Presentation, May-June, 2007, Seattle, WA. 

  • Saul, JM; Scott, JB. Development of axially-aligned scaffolds for nerve regeneration applications. North Carolina Tissue Engineering and Regenerative Medicine Society meeting. Abstract and poster, November, 2008, Research Triangle Park, NC. 

  • Scott, JB; Saul, JM. Development of axially-aligned scaffolds for optimization of neural regeneration. Society for Biomaterials. Abstract and Podium Presentation, April, 2009, San Antonio, TX. 

  • Hodges, SJ; Patel, BN; Saul, J; Kraft, R; Atala, AJ. Catheterless MRI cystogram using ultrasound activated gadolinium-containing liposomes – a pilot study. American Academy of Pediatrics National Conference and Exposition, Abstract. October, 2009, Washington, D.C.. 

  • Saul, JM; Ellenburg, MD; de Guzman RC; Van Dyke, ME. Sustained antibiotic release from keratin hydrogels. Biomedical Engineering Society, Abstract and Poster. October, 2009, Pittsburgh, PA. 

  • Scott, JB and Saul, JM. Development of intraluminal nerve scaffolds of defined length scales. Biomedical Engineering Society, Abstract and Poster, October, 2009, Pittsburgh, PA. 

  • Saul, JM; Ellenburg, MD; de Guzman, RC; Van Dyke, ME. Sustained release and bioactivity of antibiotics from keratin hydrogels. Orthopedic Research Society, Abstract, Podium, and Poster, March, 2010, New Orleans, LA. 

  • Saul, JM; Ellenburg, MD; de Guzman, RC; Van Dyke, ME. Sustained release of ciprofloxacin from keratin hydrogels for inhibition of bacterial growth. Society for Biomaterials, Abstract and Podium, April, 2010, Seattle, WA. 

  • Scott, JB; Saul, JM. Intraluminal nerve scaffolds promote axon extension in vitro. Tissue Engineering and Regenerative Medicine International Society Conference and Exposition, Abstract and Poster Presentation, December, 2010, Orlando, FL. 

  • Kowalczewski, CJ; Saul, JM. Surface-mediated delivery of small interfering ribonucleic acid polyplexes. Tissue Engineering and Regenerative Medicine International Society Conference and Exposition, Abstract and Podium Presentation, December, 2010, Orlando, FL. 

INVITED PRESENTATIONS: 

  • Michigan Technological University Department of Biomedical Engineering seminar. Houghton, MI. Non-viral gene delivery for tissue engineering applications. November 30, 2007. 

  • Wake Forest University Comprehensive Cancer Center / School of Biomedical Engineering and Sciences Retreat, Winston-Salem, NC. Systemic drug delivery of therapeutic agents in cancer. December 12, 2007. 

  • Virginia Tech School of Biomedical Engineering and Sciences Seminar, Blacksburg, VA. Non-viral gene delivery vectors and their application to regenerative medicine. April 3, 2009. 

  • Winston-Salem State University MARC Program Seminar. Winston-Salem, NC. Non-viral gene delivery vectors and their application to regenerative medicine. October 19, 2009.